It’s important to note that in some instances bioavailability isn’t the be-all and end-all, largely due to the prevalence of the endocannabinoid system throughout the body. A great example of this would be when looking at CBD topicals, such as moisturising creams and balms.
When applying a cream to your skin the bioavailability is greatly reduced since the compounds must first make their way through the epidermal layer. That means the amount of CBD that actually reaches your circulatory system is very low. However, if you’re looking for a localised external release then the CBD topical will still reach the endocannabinoid receptors in the skin.